Research

Scientific Publications 2022

sara.marchetti1@unimib.it Publications, Research
  • Bengalli B, Zerboni A, Bonfanti P, Saibene M, Mehn D, Cella C, Ponti J, La Spina R, Mantecca P. Characterization of microparticles derived from waste plastics and their bio-interaction with human lung A549 cells. J Appl Toxicol. 2022 Dec;42(12):2030-2044. doi: 10.1002/jat.4372. Epub 2022 Aug 30. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jat.4372
  • Bonfanti P, Colombo A, Saibene M, Motta G, Saliu F, Catelani T, Mehn D, La Spina R, Ponti J, Cella C, Floris P, Mantecca P. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development. Ecotoxicol Environ Saf. 2021 Dec 1;225:112775. doi: 10.1016/j.ecoenv.2021.112775. Epub 2021 Sep 15. https://www.sciencedirect.com/science/article/pii/S0147651321008873
  • Bragato C, Mostoni S, D’Abramo C, Gualtieri M, Pomilla FR, Scotti R, Mantecca P. On the In Vitro and In Vivo Hazard Assessment of a Novel Nanomaterial to Reduce the Use of Zinc Oxide in the Rubber Vulcanization Process. Toxics. 2022; 10(12):781. https://doi.org/10.3390/toxics10120781
  • Ferrero L, Scibetta L, Markuszewski P, Mazurkiewicz M, Drozdowska V, Makuch P, Jutrzenka-Trzebiatowska P, Zaleska-Medynska A, Andò S, Saliu F, Nilsson E. D, Bolzacchini E. Airborne and marine microplastics from an oceanographic survey at the Baltic Sea: An emerging role of air-sea interaction? Sci Total Environ. 2022 Jun 10;824:153709. doi: 10.1016/j.scitotenv.2022.153709. Epub 2022 Feb 9. https://pubmed.ncbi.nlm.nih.gov/35150686/
  • Ivanova A, Ivanova K, Fiandra L, Mantecca P, Catelani T, Natan M, Banin E, Jacobi G, Tzanov T. Antibacterial, Antibiofilm, and Antiviral Farnesol-Containing Nanoparticles Prevent Staphylococcus aureus from Drug Resistance Development. Int J Mol Sci. 2022 Jul 7;23(14):7527. doi: 10.3390/ijms23147527. https://www.mdpi.com/1422-0067/23/14/7527
  • Massimino L, Bulbarelli A, Corsetto P. A, Milani C, Botto L, Farina F, Lamparelli L. A, Lonati E, Ungaro F, Maddipati K. R, Palestini P, Rizzo A. M. LSEA Evaluation of Lipid Mediators of Inflammation in Lung and Cortex of Mice Exposed to Diesel Air Pollution. Biomedicines. 2022 Mar 19;10(3):712. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945792/
  • Perucca, M.; Capuano, L.; Magatti, G.; Rosa, F.; Mantecca, P. Environmental Performance of Road Asphalts Modified with End-of-Life Hard Plastics and Graphene: Strategies for Improving Sustainability. Processes 2022, 10, 2151. https://doi.org/10.3390/pr10102151
  • Traina G, Bolzacchini E, Bonini M, Contini D, Mantecca P, Caimmi S. M. E, Licari A. Role of air pollutants mediated oxidative stress in respiratory diseases. Pediatr Allergy Immunol. 2022 Jan;33 Suppl 27(Suppl 27):38-40. https://pubmed.ncbi.nlm.nih.gov/35080317/
  • Zerboni A, Rossi T, Bengalli R, Catelani T, Rizzi C, Priola M, Casadei S, Mantecca P. Diesel exhaust particulate emissions and in vitro toxicity from Euro 3 and Euro 6 vehicles. Environ Pollut. 2022 Mar 15;297:118767. https://www.sciencedirect.com/science/article/pii/S0269749121023496?via%3Dihub

Scientific Publications 2021

sara.marchetti1@unimib.it Publications, Research, Scientific Publications Archive
  • Bengalli R, Fiandra L, Vineis C, Sanchez-Ramirez DO, Azoia NG, Varesano A, Mantecca P. Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles. Nanomaterials (Basel).2021 Aug 3;11(8):1991. https://doi.org/10.3390/nano11081991
  • Bengalli R, Colantuoni A, Perelshtein I, Gedanken A, Collini M, Mantecca P, Fiandra L. In vitro skin toxicity of CuO and ZnO nanoparticles: Application in the safety assessment of antimicrobial coated textiles. 2021 Jan;21:100282. doi: 10.1016/j.impact.2020.100282. Epub 2020 Dec 7. https://doi.org/10.1016/j.impact.2020.100282
  • Bertero A, Colombo G, Cortinovis C, Bassi V, Moschini E, Bellitto N, Perego MC, Albonico M, Astori E, Dalle-Donne I, Gedanken A, Perelshtein I, Mantecca P, Caloni F. In vitro copper oxide nanoparticle toxicity on intestinal barrier. J Appl Toxicol. 2021 Feb;41(2):291-302. https://doi.org/10.1002/jat.4047
  • Bonfanti P, Colombo A, Saibene M, Motta G, Saliu F, Catelani T, Mehn D, La Spina R, Ponti J, Cella C, Floris P, Mantecca P. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development. Ecotoxicol Environ Saf. 2021 Dec 1;225:112775. https://doi.org/10.1016/j.ecoenv.2021.112775
  • Botto L, Bulbarelli A, Lonati E, Cazzaniga E, Tassotti M, Mena P, Del Rio D, Palestini P. Study of the Antioxidant Effects of Coffee Phenolic Metabolites on C6 Glioma Cells Exposed to Diesel Exhaust Particles. Antioxidants (Basel). 2021 Jul 23;10(8):1169. https://doi.org/10.3390/antiox10081169
  • Deokar AR, Perelshtein I, Saibene M, Perkas N, Mantecca P, Nitzan Y, Gedanken A. Antibacterial and In Vivo Studies of a Green, One-Pot Preparation of Copper/Zinc Oxide Nanoparticle-Coated Bandages. Membranes (Basel). 2021 Jun 22;11(7):462. https://doi.org/10.3390/membranes11070462
  • Floris P, Garbujo S, Rolla G, Giustra M, Salvioni L, Catelani T, Colombo M, Mantecca P, Fiandra L. The Role of Polymeric Coatings for a Safe-by-Design Development of Biomedical Gold Nanoparticles Assessed in Zebrafish Embryo. Nanomaterials (Basel). 2021 Apr 14;11(4):1004. https://doi.org/10.3390/nano11041004
  • Furxhi I, Bengalli R, Motta G, Mantecca P, Kose O, Carriere M, Haq EU, O’Mahony C, Blosi M, Gardini D, Costa A. Data-Driven Quantitative Intrinsic Hazard Criteria for Nanoproduct Development in a Safe-by-Design Paradigm: A Case Study of Silver Nanoforms. ACS Appl Nano Mater. 2023 Feb 16;6(5):3948-3962. doi: 10.1021/acsanm.3c00173. eCollection 2023 Mar 10. https:// org/10.1021/acsanm.3c00173
  • Kose O, Béal D, Motellier S, Pelissier N, Collin-Faure V, Blosi M, Bengalli R, Costa A, Furxhi I, Mantecca P, Carriere M. Physicochemical Transformations of Silver Nanoparticles in the Oro-Gastrointestinal Tract Mildly Affect Their Toxicity to Intestinal Cells In Vitro: An AOP-Oriented Testing Approach. Toxics. 2023 Feb 21;11(3):199. https://doi.org/10.3390/toxics11030199
  • Marchetti S., Mollerup S., Gutzkow K. B., Rizzi C., Skuland T., Refsnes M., Colombo A., Øvrevik J, Mantecca P., Holme J. A. “Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells” Toxicol in Vitro 2021 May 5;105190. https://doi.org/10.1016/j.tiv.2021.105190
  • Marchetti S., Bengalli R., Floris P., Colombo A., Mantecca P. “Combustion-derived particles from biomass sources differently promote epithelial to mesenchymal transition on A549 cells” Arch Toxicol. 2021, Jan 22. https://doi.org/10.1007/s00204-021-02983-8
  • Pacitto A, Stabile L, Morawska L, Nyarku M, Torkmahalleh MA, Akhmetvaliyeva Z, Andrade A, Dominski FH, Mantecca P, Shetaya WH, Mazaheri M, Jayaratne R, Marchetti S, Hassan SK, El-Mekawy A, Mohamed EF, Canale L, Frattolillo A, Buonanno G.Daily submicron particle doses received by populations living in different low- and middle-income countries. Environ Pollut. 2021 Jan 15;269:116229.https://doi.org/10.1016/j.envpol.2020.116229
  • Zerboni A, Bengalli R, Fiandra L, Catelani T, Mantecca P. Cellular Mechanisms Involved in the Combined Toxic Effects of Diesel Exhaust and Metal Oxide Nanoparticles. Nanomaterials (Basel). 2021, May 29;11(6):1437.https://doi.org/10.3390/nano11061437

Scientific Publications 2020

sara.marchetti1@unimib.it Publications, Research, Scientific Publications Archive
  • Bonfanti P, Colombo A, Saibene M, Fiandra L, Armenia I, Gamberoni F, Gornati R, Bernardini G, Mantecca P. Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles. Nanotoxicology. 2020 Mar;14(2):196-213. https://doi.org/10.1080/17435390.2019.1685695
  • Borgese M, Rossi F, Bonfanti P, Colombo A, Mantecca P, Valdatta L, Bernardini G, Gornati R. Recovery ability of human adipose stem cells exposed to cobalt nanoparticles: outcome of dissolution. Nanomedicine (Lond). 2020 Feb;15(5):453-465. https://doi.org/10.2217/nnm-2019-0195
  • Comunian S, Dongo D, Milani C, Palestini P. Air Pollution and Covid-19: The Role of Particulate Matter in the Spread and Increase of Covid-19’s Morbidity and Mortality. Int J Environ Res Public Health. 2020 Jun 22;17(12):4487. https://doi.org/10.3390/ijerph17124487
  • Longhin EM, Mantecca P, Gualtieri M.Fifteen Years of Airborne Particulates in Vitro Toxicology in Milano: Lessons and Perspectives Learned. Int J Mol Sci. 2020 Apr 3;21(7):2489. https://doi.org/10.3390/ijms21072489
  • Milani C, Farina F, Botto L, Massimino L, Lonati E, Donzelli E, Ballarini E, Crippa L, Marmiroli P, Bulbarelli A, Palestini P. Systemic Exposure to Air Pollution Induces Oxidative Stress and Inflammation in Mouse Brain, Contributing to Neurodegeneration Onset. Int J Mol Sci. 2020 May 24;21(10):3699. https://doi.org/10.3390/ijms21103699
  • Traina G, Barbalace A, Betti F, Bolzacchini E, Bonini M, Contini D, Felice G, Foti T, Mantecca P. What impact of air pollution in pediatric respiratory allergic diseases. Pediatr Allergy Immunol. 2020 Nov;31 Suppl 26:26-28. https://doi.org/10.1111/pai.13362

ASINA – Anticipating Safety Issues at the Design Stage of NAno Product Development

serviziwebsi@unimib.it Research Projects
ASINA – Anticipating Safety Issues at the Design Stage of NAno Product Development

Il progetto Horizon 2020 ASINA (Anticipating safety issues at the design stage of nano product development) si propone di implementare strategie di “safe-by-design” per lo sviluppo di nanomateriali intrinsecamente sicuri, che siano a basso rischio, per la salute dell’uomo e dell’ambiente. ASINA è coordinato dal Cnr-ISTEC che vede la partecipazione di 21 membri, tra i quali centri di ricerca, università, SMEs, e oranizzazioni non governative (NGOs) europee e non, afferenti a 8 diversi Paesi europei. Il titolo della call alla quale abbiamo risposto è: “Safe for design: from science to regulation”.

Project Coordinator Prof.  Anna Luisa Costa

Dissemination Manager Dr. Isella Vicini

Partner UNIMIB – POLARIS (Paride Mantecca) is leader of WP2 -MATERIAL SAFETY DESIGN CRITERIA, i cui obbiettivi sono:

  • determinare i design criteria per l’esposizione a NMs, tramite l’identificazione di parametri p-chem (chimico-fisici) che modulano le risposte biologiche in termini di scenari di esposizione
  • determinare i design criteria per l’esposizione a NMs, tramite l’identificazione di parametri p-chem (chimico-fisici) che modulano risposte biologiche in seguito ad un evento molecolare iniziale e/o specifici step presenti all’interno di adverse outcome pathways (AOPs) già caratterizzati
  • utilizzo e adattamento di frameworks per calcolo del rischio (risk assessment) nel contesto di ASINA, fornendo indicazioni pratiche per il read-across di materiali

Per informazioni:

ASINA Web site

CNR Web site

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