Work with us

Work with us

New PhD position available!

Project title: New approach methodologies to assess the biological safety and mechanisms of action of advanced (nano)materials

The project will develop new advanced in vitro models of the lung barrier, exposed at the air-liquid-interface (ALI) with dedicated systems, to better mimicking the physiological conditions of exposure and responses to airborne particles and molecules. The new biological systems, based on the interplay of lung epithelial, endothelial and/or immune cells, also in combination with a 3D bio-printed extracellular matrix will be used to implement an adverse outcomes pathways (AOPs)-based approach to characterize the cytotoxic and proinflammatory effects of new nano(bio)materials and airborne pollutants. The project aims at establishing New Approach Methodologies (NAMs) combining advanced exposure systems, complex predictive biological models and molecular/omics, coupled with morphological approaches. A strong scientific contribution is expected in the fields of environmental toxicology and health and safety assessment of new chemicals and materials.

The PhD project is within the EU project INTEGRANO (Multidimensional Integrated Quantitative Approach to Assess Safety and Sustainability of Nanomaterials in Real Case Life Cycle Scenarios Using Nanospecific Impact Categories), HORIZON CL 4 2023 RESILIENCE 01 22 (GA n 101138414).

Tutor: Paride Mantecca

Supervisors: Maurizio Gualtieri, Laura Russo

The selection for admission to the 40th cycle PhD programme in Converging Technologies for Biomolecular Systems (UNIMIB) is open.

Please visit the Calls for Application section to get more information.

INTEGRANO

INTEGRANO

UNIMIB is coordinator of a new Horizon Europe project: INTEGRANO (GA. 101138414)

In line with the current guidelines for Safe and Sustainable by Design – SSbD chemicals and materials, INTEGRANO proposes a general assessment approach based on quantitative evidence to be applied in practice for specific Nano Materials (NMs) design cases.
INTEGRANO ambition is to set the basis for a new paradigm based on standardised frameworks and by creating suitable NMs datasets as well as Nanospecific impact categories of NMs through their Life Cycle Stages (LCS), applied to specific design cases assessment.

12 partners from 8 different countries participate in the hashtagIntegrano Project. This network allows for different expertises and skills within the project, which complement and support each other

For further information visit INTEGRANO page, the website INTEGRANO – INTEGRANO or the Linkedin page.

New Article published!

New Article published!

What is the connection between pollution and COVID19?

The POLARIS “Health and Environmental Sustainability” Research Centre has demonstrated how air pollution can play a crucial role in the transmission of the SARS-CoV-2 virus and the resulting severity of the COVID-19 disease. The study, recently published in the journal Environment International, paves the way for a greater understanding of how atmospheric particulate matter can influence and facilitate the possibility of contracting respiratory diseases transmitted by viruses or bacteria and provides fundamental information to understand how the population responds to the same threat depending on the quality of the environment in which it lives.

To find out more, read the interview with our researchers, edited by the press office of the University of Milan-Bicocca.

Further information on Environment International:

Marchetti S, Gualtieri M, Pozzer A, Lelieveld J, Saliu F, Hansell AL, Colombo A, Mantecca P. On fine particulate matter and COVID-19 spread and severity: An in vitro toxicological plausible mechanism.