Research

BIOMAT

sara.marchetti1@unimib.it Research Projects , ,
BIOMAT

BIOMAT – Open  Innovation Test Bed for Nano-Enabled Bio-Based PUR Foams and composites

The POLARIS Research Center is involved in the European BIOMAT project, funded by the European Commission in the Horizon 2020 framework (Grant Agreement nr.) with the aim of establishing an Open Innovation Test Bed (BIOMAT-TB) with a Single-Entry Point (SEP) . The aim of this project is to accelerate a sustainable European bioeconomy through the development of nanomaterial-based and advanced polyurethane foams (PUR Foams) for various companies (building, construction, automotive, furniture, textiles).

Project ID:953270; Call ID: H2020-EU.2.1.3. – INDUSTRIAL LEADERSHIP – Leadership in enabling and industrial technologies – Advanced materials;   H2020-EU.2.1.2. – INDUSTRIAL LEADERSHIP – Leadership in enabling and industrial technologies – Nanotechnologies

Project coordinator: Dr. Mariana Ornelas (CENTI)

Dissemination Manager: Dr. Pnina Dan (OSM-DAN LTD).

Partner UNIMIB – POLARIS Prof. Paride Mantecca is leader of WP7 – Recycling technologies, nanosafety and regulatory issues with specific focus on Nanosafety and toxicology (Task 7.2).

Further information can be found at the link.

Discover more on the project here!

 

Research

sara.marchetti1@unimib.it Research
Research

The Interdepartmental Research Centre called “Environmental Health and Sustainability – POLARIS” aims to increase and integrate the state of knowledge in the following macro-areas of research:

AIR QUALITY AND HEALTH

Monitoring of air quality in indoor and outdoor environments and study of the impact on human and environmental health, with focus on the presence of air contaminants and the spread of pathogens.

Recent Projects:

MUSA
IT-BEST

To find out more, visit the dedicated page

INNOVATIVE, SAFE AND SUSTAINABLE TECHNOLOGIES

Support for the development of safe, sustainable and innovative (nano)technologies, with assessment of their safety during the entire life cycle (circularity). Study of emerging contaminants, their impact on health and risk prevention and mitigation strategies.

Recent Projects:

INTEGRANO
AMYGIN

To find out more, visit the dedicated page

ENVIRONMENTAL ECONOMICS AND SOCIOLOGY

Evaluation of the environmental, economic and social impacts of products and processes; development of environmental policies with a view to sustainability and circularity.

Recent Projects:

To find out more, visit the dedicated page

Scientific Publications 2021

sara.marchetti1@unimib.it Publications, Research, Scientific Publications Archive
  • Bengalli R, Fiandra L, Vineis C, Sanchez-Ramirez DO, Azoia NG, Varesano A, Mantecca P. Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles. Nanomaterials (Basel).2021 Aug 3;11(8):1991. https://doi.org/10.3390/nano11081991
  • Bengalli R, Colantuoni A, Perelshtein I, Gedanken A, Collini M, Mantecca P, Fiandra L. In vitro skin toxicity of CuO and ZnO nanoparticles: Application in the safety assessment of antimicrobial coated textiles. 2021 Jan;21:100282. doi: 10.1016/j.impact.2020.100282. Epub 2020 Dec 7. https://doi.org/10.1016/j.impact.2020.100282
  • Bertero A, Colombo G, Cortinovis C, Bassi V, Moschini E, Bellitto N, Perego MC, Albonico M, Astori E, Dalle-Donne I, Gedanken A, Perelshtein I, Mantecca P, Caloni F. In vitro copper oxide nanoparticle toxicity on intestinal barrier. J Appl Toxicol. 2021 Feb;41(2):291-302. https://doi.org/10.1002/jat.4047
  • Bonfanti P, Colombo A, Saibene M, Motta G, Saliu F, Catelani T, Mehn D, La Spina R, Ponti J, Cella C, Floris P, Mantecca P. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development. Ecotoxicol Environ Saf. 2021 Dec 1;225:112775. https://doi.org/10.1016/j.ecoenv.2021.112775
  • Botto L, Bulbarelli A, Lonati E, Cazzaniga E, Tassotti M, Mena P, Del Rio D, Palestini P. Study of the Antioxidant Effects of Coffee Phenolic Metabolites on C6 Glioma Cells Exposed to Diesel Exhaust Particles. Antioxidants (Basel). 2021 Jul 23;10(8):1169. https://doi.org/10.3390/antiox10081169
  • Deokar AR, Perelshtein I, Saibene M, Perkas N, Mantecca P, Nitzan Y, Gedanken A. Antibacterial and In Vivo Studies of a Green, One-Pot Preparation of Copper/Zinc Oxide Nanoparticle-Coated Bandages. Membranes (Basel). 2021 Jun 22;11(7):462. https://doi.org/10.3390/membranes11070462
  • Floris P, Garbujo S, Rolla G, Giustra M, Salvioni L, Catelani T, Colombo M, Mantecca P, Fiandra L. The Role of Polymeric Coatings for a Safe-by-Design Development of Biomedical Gold Nanoparticles Assessed in Zebrafish Embryo. Nanomaterials (Basel). 2021 Apr 14;11(4):1004. https://doi.org/10.3390/nano11041004
  • Furxhi I, Bengalli R, Motta G, Mantecca P, Kose O, Carriere M, Haq EU, O’Mahony C, Blosi M, Gardini D, Costa A. Data-Driven Quantitative Intrinsic Hazard Criteria for Nanoproduct Development in a Safe-by-Design Paradigm: A Case Study of Silver Nanoforms. ACS Appl Nano Mater. 2023 Feb 16;6(5):3948-3962. doi: 10.1021/acsanm.3c00173. eCollection 2023 Mar 10. https:// org/10.1021/acsanm.3c00173
  • Kose O, BĂŠal D, Motellier S, Pelissier N, Collin-Faure V, Blosi M, Bengalli R, Costa A, Furxhi I, Mantecca P, Carriere M. Physicochemical Transformations of Silver Nanoparticles in the Oro-Gastrointestinal Tract Mildly Affect Their Toxicity to Intestinal Cells In Vitro: An AOP-Oriented Testing Approach. Toxics. 2023 Feb 21;11(3):199. https://doi.org/10.3390/toxics11030199
  • Marchetti S., Mollerup S., Gutzkow K. B., Rizzi C., Skuland T., Refsnes M., Colombo A., Øvrevik J, Mantecca P., Holme J. A. “Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells” Toxicol in Vitro 2021 May 5;105190. https://doi.org/10.1016/j.tiv.2021.105190
  • Marchetti S., Bengalli R., Floris P., Colombo A., Mantecca P. “Combustion-derived particles from biomass sources differently promote epithelial to mesenchymal transition on A549 cells” Arch Toxicol. 2021, Jan 22. https://doi.org/10.1007/s00204-021-02983-8
  • Pacitto A, Stabile L, Morawska L, Nyarku M, Torkmahalleh MA, Akhmetvaliyeva Z, Andrade A, Dominski FH, Mantecca P, Shetaya WH, Mazaheri M, Jayaratne R, Marchetti S, Hassan SK, El-Mekawy A, Mohamed EF, Canale L, Frattolillo A, Buonanno G.Daily submicron particle doses received by populations living in different low- and middle-income countries. Environ Pollut. 2021 Jan 15;269:116229.https://doi.org/10.1016/j.envpol.2020.116229
  • Zerboni A, Bengalli R, Fiandra L, Catelani T, Mantecca P. Cellular Mechanisms Involved in the Combined Toxic Effects of Diesel Exhaust and Metal Oxide Nanoparticles. Nanomaterials (Basel). 2021, May 29;11(6):1437.https://doi.org/10.3390/nano11061437

Scientific Publications 2020

sara.marchetti1@unimib.it Publications, Research, Scientific Publications Archive
  • Bonfanti P, Colombo A, Saibene M, Fiandra L, Armenia I, Gamberoni F, Gornati R, Bernardini G, Mantecca P. Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles. Nanotoxicology. 2020 Mar;14(2):196-213. https://doi.org/10.1080/17435390.2019.1685695
  • Borgese M, Rossi F, Bonfanti P, Colombo A, Mantecca P, Valdatta L, Bernardini G, Gornati R. Recovery ability of human adipose stem cells exposed to cobalt nanoparticles: outcome of dissolution. Nanomedicine (Lond). 2020 Feb;15(5):453-465. https://doi.org/10.2217/nnm-2019-0195
  • Comunian S, Dongo D, Milani C, Palestini P. Air Pollution and Covid-19: The Role of Particulate Matter in the Spread and Increase of Covid-19’s Morbidity and Mortality. Int J Environ Res Public Health. 2020 Jun 22;17(12):4487. https://doi.org/10.3390/ijerph17124487
  • Longhin EM, Mantecca P, Gualtieri M.Fifteen Years of Airborne Particulates in Vitro Toxicology in Milano: Lessons and Perspectives Learned. Int J Mol Sci. 2020 Apr 3;21(7):2489. https://doi.org/10.3390/ijms21072489
  • Milani C, Farina F, Botto L, Massimino L, Lonati E, Donzelli E, Ballarini E, Crippa L, Marmiroli P, Bulbarelli A, Palestini P. Systemic Exposure to Air Pollution Induces Oxidative Stress and Inflammation in Mouse Brain, Contributing to Neurodegeneration Onset. Int J Mol Sci. 2020 May 24;21(10):3699. https://doi.org/10.3390/ijms21103699
  • Traina G, Barbalace A, Betti F, Bolzacchini E, Bonini M, Contini D, Felice G, Foti T, Mantecca P. What impact of air pollution in pediatric respiratory allergic diseases. Pediatr Allergy Immunol. 2020 Nov;31 Suppl 26:26-28. https://doi.org/10.1111/pai.13362

ASINA – Anticipating Safety Issues at the Design Stage of NAno Product Development

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ASINA – Anticipating Safety Issues at the Design Stage of NAno Product Development

Il progetto Horizon 2020 ASINA (Anticipating safety issues at the design stage of nano product development) si propone di implementare strategie di “safe-by-design” per lo sviluppo di nanomateriali intrinsecamente sicuri, che siano a basso rischio, per la salute dell’uomo e dell’ambiente. ASINA è coordinato dal Cnr-ISTEC che vede la partecipazione di 21 membri, tra i quali centri di ricerca, università, SMEs, e oranizzazioni non governative (NGOs) europee e non, afferenti a 8 diversi Paesi europei. Il titolo della call alla quale abbiamo risposto è: “Safe for design: from science to regulation”.

Project Coordinator Prof.  Anna Luisa Costa

Dissemination Manager Dr. Isella Vicini

Partner UNIMIB – POLARIS (Paride Mantecca) is leader of WP2 -MATERIAL SAFETY DESIGN CRITERIA, i cui obbiettivi sono:

  • determinare i design criteria per l’esposizione a NMs, tramite l’identificazione di parametri p-chem (chimico-fisici) che modulano le risposte biologiche in termini di scenari di esposizione
  • determinare i design criteria per l’esposizione a NMs, tramite l’identificazione di parametri p-chem (chimico-fisici) che modulano risposte biologiche in seguito ad un evento molecolare iniziale e/o specifici step presenti all’interno di adverse outcome pathways (AOPs) giĂ  caratterizzati
  • utilizzo e adattamento di frameworks per calcolo del rischio (risk assessment) nel contesto di ASINA, fornendo indicazioni pratiche per il read-across di materiali

Per informazioni:

ASINA Web site

CNR Web site

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