This page provides an overview of the main research areas in which the POLARIS Interdepartmental Research Centre is involved.
AIR QUALITY AND HEALTH
Monitoring of air quality in indoor and outdoor environments and study of the impact on human and environmental health, with focus on the presence of air contaminants and the spread of pathogens.
Recent Projects:
INNOVATIVE, SAFE AND SUSTAINABLE TECHNOLOGIES
Support for the development of safe, sustainable and innovative (nano)technologies, with assessment of their safety during the entire life cycle (circularity). Study of emerging contaminants, their impact on health and risk prevention and mitigation strategies.
Recent Projects:
ENVIRONMENTAL ECONOMICS AND SOCIOLOGY
Evaluation of the environmental, economic and social impacts of products and processes; development of environmental policies with a view to sustainability and circularity.
MEETmeTonight, the event dedicated to scientific dissemination during the European Researchers’ Night, returns to Milan. This new edition includes two days of free initiatives open to all ages with stands, talks, workshops and shows.
Heart of the program are the 5 European Missions – adaptation to climate change; fight against cancer; protection of oceans, seas, lakes and rivers; climate-neutral and intelligent cities; soil health – expressed in numerous activities involving professors, researchers and young PhDs.
The event is organized by 5 universities in Milan – University of Milan-Bicocca, University of Milan, Bocconi University, Polytechnic University of Milan and Vita-Salute San Raffaele University – and by formicablu. It is a unique opportunity to get closer to the world of research, science and innovation.
In this context, the POLARIS research centre will be present at the event with a thematic stand at the Science Park in Viale Sarca (near Bicocca Stadium). At the SC06 stand entitled “SMART SENS – test the quality of your environment!” the researchers will show their research activities to the public.
The proposed activity aims to explore the topic of air quality from different points of view. The stand includes various instruments for measuring air pollutants, from scientific-level instruments to low-cost instruments, such as ‘smart’ sensors used by the POLARIS Interdepartmental Centre within the Open-Living lab of the MUSA – Multilayered Urban Sustainability Action project, funded by the European Union – NextGenerationEU, PNRR Mission 4 Component 2 Investment Line 1.5: Creation and strengthening of “innovation ecosystems”, construction of “territorial R&D leaders” (Spoke 1 – Urban Regeneration. City of Tomorrow, WP1).
The public will learn how these instruments work and the main environmental monitoring techniques. Additionally, part of the experience also includes an in-depth look at the effects of these pollutants on our respiratory system.
In the afternoon, researchers from the POLARIS Centre will also be involved in the workshop entitled “What do you breathe in your neighborhood? Understanding the urban environment by walking” organized together with researchers from CEMTET (Research Center on Mobility, Tourism and Territory) which will be held in the U7 building (via Padre Gerardo Beccaro 20).
The workshop, aimed at adults and boys and girls aged 14 and up, offers a collective experience of observing the Bicocca district to explore its accessibility and inclusiveness. You can participate in this workshop in two time slots (14:00-16:30, 16:30-19:00). Sign up to attend: registration is required on Eventbrite at the link. There are 15 spots available for each time slot.
The quality of the air we breathe every day is often influenced by our lifestyle choices, which can determine the release of particles and other pollutants into the atmosphere, with a huge impact on our health.
The activity proposed by the workshop presents an interdisciplinary and interactive approach to explore the topic of air quality from different points of view. The proposal for an itinerant activity aims to collect data on the air quality of the neighborhood, also considering how different sources of pollutants in closed (indoor) and open (outdoor) environments or how mobility choices can affect personal exposure.
XXVI Conference “Methods, Practices, and Policies for the Future of Mobility”
On September 19 and 20 2024, the University of Milan-Bicocca will host the 26th edition of the Conference of the The Italian Society of Transport and Logistics Economists (SIET), entitled “Methods, Practices, and Policies for the Future of Mobility”
The conference is organized by the Department of Economics, Quantitative Methods and Strategy and the Department of Sociology and Social Research.
In this perspective, on Friday 20 September from 11.30 to 13.30 in the De Lillo room the thematic session “Environmental sciences meet Transport Economy: challenges in sustainability promotion and monitoring solutions” will take place, is sponsored by the POLARIS research centre.
The session, chaired by Dr. Simone Caiello and Prof. Luca Ferrero, will delve into the relationship between Mobility and Air Quality, thanks to the contributions of professors and researchers on air pollutants and their implications on health and climate, as well as on the strategies that can be implemented to promote increasingly sustainable mobility and logistics.
The XXVI Conference of the Italian Society of Transport Economics and Logistics (SIET) will be on the September 19-20 2024 at the campus of University of Milano-Bicocca. The conference is organized by the Department of Economics, Quantitative Methods and Strategy and the Department of Sociology and Social Research.
In the multidisciplinary and interdepartmental spirit of the POLARIS Research Centre, a session entitled “Environmental sciences meet Transport Economy: challenges in sustainable promotion and monitoring solutions” was proposed, sponsored by the Centre itself.
Interested presenters should submit an abstract by April 30, 2024, to siet2024milano@gmail.com, indicating “Polaris session” in the subject. Proposals for communications on topics of interest to the Centre will be welcomed. The proposed session will provide a unique platform for a multidisciplinary exchange between experts and academicians from different fields.
The Safe-by-Design concept (SbD) incorporates safety of nano-enabled product (NEP) at the design stage of the production process. SbD reverses the paradigm of downstream risk analysis and management (‘is it safe?’, ‘can it be controlled?’, ‘does it transform?’) and pursues the production of less hazardous nano-products affording reduced exposure, mediated by the release of nanomaterials during the life-cycle. The SbD production of NEPs has been recently elaborated upon, and several EU funded projects have provided some tools, databases, and case studies for its implementation.
Despite the advantages that can be obtained, the current state of the art indicates that industrial production is struggling to activate the SbD approach and the fast industrial uptake of engineered nanomaterials (NMs) is missing or unsafely implemented. The delay of nanomanufacturing implementation in the industry is due to incorrect use, lack of NMs culture, and/or difficult access to better quality NMs due to cost or logistics reasons. Psychological difficulties due to the use of unregulated substances, easy access to non-quality-certified NMs, difficulties in following the fast technological evolution of NMs also play a role.
ASINA aims to:
support the fast industrial uptake of nanotechnology by providing Safe-by-Design solutions and supporting tools;
to give entrepreneurs knowledge and awareness of Safe-by-Design potential;
to increase confidence in Safe-by-Design nanomanufacturing by improving the interaction and integration of different stakeholders (entrepreneurs, scientists, regulators, innovators, policy makers).
For this purpose, the proposal will take into consideration the important nano design features of coating and encapsulation and related Value Chains (VCs). ASINA will develop a specific Safe-by-Design Management Methodology, consistent with modern business management systems, to deliver Safe-by-Design solutions and inform design decisions. The project will establish a pilot action, involving test beds and pilot plants, for testing and validating the methodology contents as specific implementations that can be generalized to other engineered nanomaterials, nano-enabled products and industrial case studies. ASINA will finally export the methodology to the industry through a roadmap (including guidelines, analytical tools, best practices) and other standardization deliverables such as CEN-CWA, as a realistic way to ensure diffusion of the ASINA SMM and its industrial implementation worldwide.
PROJECT DETAILS:
PROJECT TITLE: Anticipating Safety Issues at the Design Stage of NAno Product Development
ACRONYM: ASINA
START DATE: 01 March 2020
END DATE: 28 February 2024
TOPIC: NMBP-15-2019 Safe by design, from science to regulation: metrics and main sectors (RIA)
The Safe and Sustainable by Design (SSbD) framework aims to steer the innovation process towards the green and sustainable industrial transition, substitute or minimise the production and use of substances of concern, and minimise the impact on health, climate and the environment during sourcing, production, use and end-of-life of chemicals, materials and products. However, SSbD implementation to nanomaterials (NMs) is hampered by a lack of harmonized or specific data and datasets which poses a challenge to the design of safe and sustainable NMs and their incorporation into nano-enabled products (NEPs).
INTEGRANO aims to:
• Support decision making in NM development, enabling stakeholders (scientists, material engineers, policymakers) to tackle the SSbD challenge in the NM context
• Promote the design and redesign of NMs and NEPs by reducing R&D and approval lead time, minimising costs and increasing data transparency
• To support industry by reducing research and technological development and innovation risk related to safety and sustainability by enabling impact-based informed investment decisions
UNIMIB is project coordinator of the project and leader of WP3, which aims at nano-tox and nano eco-tox data generation.
Tseberlidis G., Trifiletti V., Husien A.H., L’Altrella A., Binetti S, Gosetti F. Cu2ZnSnS4 Nanoparticles as an Efficient Photocatalyst for the Degradation of Diclofenac in Water. Appl. Sci. 2024, 14, 9923. DOI: 10.3390/app14219923
Gualtieri M, Melzi G, Costabile F, Stracquadanio M, La Torretta T, Di Iulio G, Petralia E, Rinaldi M, Paglione M, Decesari S, Mantecca P, Corsini E. On the dose-response association of fine and ultrafine particles in an urban atmosphere: toxicological outcomes on bronchial cells at realistic doses of exposure at the Air Liquid Interface. Chemosphere. 2024 Sep 28:366:143417. DOI: 10.1016/j.chemosphere.2024.143417
Marchetti S, Colombo A, Saibene M, Bragato C, La Torretta T, Rizzi C, Gualtieri M, Paride Mantecca P. Shedding light on the cellular mechanisms involved in the combined adverse effects of fine particulate matter and SARS-CoV-2 on human lung cells. Sci Total Environ. 2024 Nov 20:952:175979. DOI: 10.1016/j.scitotenv.2024.175979
Botto L, Bulbarelli A, Lonati E, Cazzaniga E, Palestini P. Correlation between Exposure to UFP and ACE/ACE2 Pathway: Looking for Possible Involvement in COVID-19 Pandemic. Toxics. 2024 Jul 31;12(8):560. DOI: 10.3390/toxics12080560
Bragato C, Persico A, Ferreres G, Tzanov T, Mantecca P. Exploring the Effects of Lignin Nanoparticles in Different Zebrafish Inflammatory Models. Int J Nanomedicine. 2024 Jul 30:19:7731-7750. DOI: 10.2147/IJN.S469813
Furxhi I, Perucca M, Koivisto AJ, Bengalli R, Mantecca P, Nicosia A, Burrueco-Subirà D, Vázquez-Campos S, Lahive E, Blosi M, Lopez de Ipiña J, Oliveira J, Carriere M, Vineis C, Costa A. A roadmap towards safe and sustainable by design nanotechnology: Implementation for nano-silver-based antimicrobial textile coatings production by ASINA project. Comput Struct Biotechnol J. 2024 Jun 15:25:127-142. DOI: 10.1016/j.csbj.2024.06.013
Bragato C, Mazzotta R, Persico A, Bengalli R, Ornelas M, Gomes F, Bonfanti P, Mantecca P. Biocompatibility Analysis of Bio-Based and Synthetic Silica Nanoparticles during Early Zebrafish Development. Int J Mol Sci. 2024 May 18;25(10):5530. DOI: 10.3390/ijms25105530
Saibene M, Serchi T, Bonfanti P, Colombo A, Nelissen I, Halder R, Audinot JN, Pelaz B, Soliman MG, Parak WJ, Mantecca P, Gutleb AC, Cambier S. The use of a complex tetra-culture alveolar model to study the biological effects induced by gold nanoparticles with different physicochemical properties. Environ Toxicol Pharmacol. 2024 Mar:106:104353. DOI: 10.1016/j.etap.2023.104353
Perelshtein I, Shoshani S, Jacobi G, Natan M, Dudchenko N, Perkas N, Tkachev M, Bengalli R, Fiandra L, Mantecca P, Ivanova K, Tzanov T, Banin E, Gedanken A. Protecting the Antibacterial Coating of Urinal Catheters for Improving Safety. ACS Appl Bio Mater. 2024 Feb 19;7(2):990-998. DOI: 10.1021/acsabm.3c00988
Motta G, Gualtieri M, Bengalli R, Saibene M, Belosi F, Nicosia A, Cabellos J, Mantecca P. An integrated new approach methodology for inhalation risk assessment of safe and sustainable by design nanomaterials. Environ Int. 2024 Jan:183:108420. DOI: 10.1016/j.envint.2024.108420
UNIMIB is coordinator of a new Horizon Europe project: INTEGRANO (GA. 101138414).
In line with the current guidelines for Safe and Sustainable by Design – SSbD chemicals and materials, INTEGRANO proposes a general assessment approach based on quantitative evidence to be applied in practice for specific Nano Materials (NMs) design cases.
INTEGRANO ambition is to set the basis for a new paradigm based on standardised frameworks and by creating suitable NMs datasets as well as Nanospecific impact categories of NMs through their Life Cycle Stages (LCS), applied to specific design cases assessment.
12 partners from 8 different countries participate in the hashtagIntegrano Project. This network allows for different expertises and skills within the project, which complement and support each other.
Bengalli RD, Zerbi G, Lucotti A, Catelani T, Mantecca P. Carbon nanotubes: Structural defects as stressors inducing lung cell toxicity. Chem Biol Interact. 2023 Sep 1;382:110613. https://doi.org/10.1016/j.cbi.2023.110613
Botto L, Lonati E, Russo S, Cazzaniga E, Bulbarelli A, Palestini P. Effects of PM2.5 Exposure on the ACE/ACE2 Pathway: Possible Implication in COVID-19 Pandemic. Int J Environ Res Public Health. 2023 Mar 1;20(5):4393. https://doi.org/10.3390/ijerph20054393
Bragato C, Pistocchi A, Bellipanni G, Confalonieri S, Balciunie J, Monastra FM, Carra S, Vitale G, Mantecca P, Cotelli F, Gaudenzi G. Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. J Neurosci Res. 2023 Apr 9. https://doi.org/1002/jnr.25197.
Gualtieri M, Carriere M, Mantecca P. Hazard, Distribution and Exposure of Particulate Pollution from Indoor and Outdoor Environments.Toxics. 2023 Sep 12;11(9):772. https://doi.org/10.3390/toxics11090772
Kose O, Béal D, Motellier S, Pelissier N, Collin-Faure V, Blosi M, Bengalli R, Costa A, Furxhi I, Mantecca P, Carriere M. Physicochemical Transformations of Silver Nanoparticles in the Oro-Gastrointestinal Tract Mildly Affect Their Toxicity to Intestinal Cells In Vitro: An AOP-Oriented Testing Approach. Toxics. 2023; 11(3):199. https://doi.org/10.3390/toxics11030199
Kose O, Mantecca P, Costa A, Carrière M. Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review. Part Fibre Toxicol. 2023 Jan 5;20(1):1. https://doi.org/1186/s12989-022-00511-9
Marchetti S., Gualtieri M., Pozzer A, Lelieveld J., Hansell A. L., Colombo A., Mantecca P. On fine particulate matter and COVID-19 spread and severity: an in vitro toxicological plausible mechanism. Environ Int. 179 (2023) 108131. https://doi.org/10.1016/j.envint.2023.108131
Moschini E, Colombo G, Chirico G, Capitani G, Dalle-Donne I, Mantecca P. Biological mechanism of cell oxidative stress and death during short-term exposure to nano CuO. Sci Rep. 2023 Feb 9;13(1):2326. https://doi.org/1038/s41598-023-28958-6
Motta G, Gualtieri M, Saibene M, Bengalli R, Brigliadori A, Carrière M, Mantecca P. Preliminary Toxicological Analysis in a Safe-by-Design and Adverse Outcome Pathway-Driven Approach on Different Silver Nanoparticles: Assessment of Acute Responses in A549 Cells. Toxics. 2023; 11(2):195. https://doi.org/10.3390/toxics11020195
