Author: sara.marchetti1@unimib.it

INTEGRANO

sara.marchetti1@unimib.it News and Events, Research ,
INTEGRANO

UNIMIB is coordinator of a new Horizon Europe project: INTEGRANO (GA. 101138414).

In line with the current guidelines for Safe and Sustainable by Design – SSbD chemicals and materials, INTEGRANO proposes a general assessment approach based on quantitative evidence to be applied in practice for specific Nano Materials (NMs) design cases.
INTEGRANO ambition is to set the basis for a new paradigm based on standardised frameworks and by creating suitable NMs datasets as well as Nanospecific impact categories of NMs through their Life Cycle Stages (LCS), applied to specific design cases assessment.

12 partners from 8 different countries participate in the Integrano Project. This network allows for different expertises and skills within the project, which complement and support each other.

For further information visit INTEGRANO page, the website INTEGRANO – INTEGRANO or the Linkedin page.

Scientific Publications 2023

sara.marchetti1@unimib.it Publications, Research
  • Bengalli RD, Zerbi G, Lucotti A, Catelani T, Mantecca P. Carbon nanotubes: Structural defects as stressors inducing lung cell toxicity. Chem Biol Interact. 2023 Sep 1;382:110613. https://doi.org/10.1016/j.cbi.2023.110613
  • Botto L, Lonati E, Russo S, Cazzaniga E, Bulbarelli A, Palestini P. Effects of PM2.5 Exposure on the ACE/ACE2 Pathway: Possible Implication in COVID-19 Pandemic. Int J Environ Res Public Health. 2023 Mar 1;20(5):4393. https://doi.org/10.3390/ijerph20054393
  • Bragato C, Pistocchi A, Bellipanni G, Confalonieri S, Balciunie J, Monastra FM, Carra S, Vitale G, Mantecca P, Cotelli F, Gaudenzi G. Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. J Neurosci Res. 2023 Apr 9. https://doi.org/1002/jnr.25197.
  • Gualtieri M, Carriere M, Mantecca P. Hazard, Distribution and Exposure of Particulate Pollution from Indoor and Outdoor Environments.Toxics. 2023 Sep 12;11(9):772. https://doi.org/10.3390/toxics11090772
  • Kose O, Béal D, Motellier S, Pelissier N, Collin-Faure V, Blosi M, Bengalli R, Costa A, Furxhi I, Mantecca P, Carriere M. Physicochemical Transformations of Silver Nanoparticles in the Oro-Gastrointestinal Tract Mildly Affect Their Toxicity to Intestinal Cells In Vitro: An AOP-Oriented Testing Approach. Toxics. 2023; 11(3):199. https://doi.org/10.3390/toxics11030199
  • Kose O, Mantecca P, Costa A, Carrière M. Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review. Part Fibre Toxicol. 2023 Jan 5;20(1):1. https://doi.org/1186/s12989-022-00511-9
  • Marchetti S., Gualtieri M., Pozzer A, Lelieveld J., Hansell A. L., Colombo A., Mantecca P. On fine particulate matter and COVID-19 spread and severity: an in vitro toxicological plausible mechanism. Environ Int. 179 (2023) 108131. https://doi.org/10.1016/j.envint.2023.108131
  • Moschini E, Colombo G, Chirico G, Capitani G, Dalle-Donne I, Mantecca P. Biological mechanism of cell oxidative stress and death during short-term exposure to nano CuO. Sci Rep. 2023 Feb 9;13(1):2326. https://doi.org/1038/s41598-023-28958-6
  • Motta G, Gualtieri M, Saibene M, Bengalli R, Brigliadori A, Carrière M, Mantecca P. Preliminary Toxicological Analysis in a Safe-by-Design and Adverse Outcome Pathway-Driven Approach on Different Silver Nanoparticles: Assessment of Acute Responses in A549 Cells. Toxics. 2023; 11(2):195. https://doi.org/10.3390/toxics11020195

BIOMAT

sara.marchetti1@unimib.it Air quality and health, Research Projects

BIOMAT – Open  Innovation Test Bed for Nano-Enabled Bio-Based PUR Foams and composites

The POLARIS Research Center is involved in the European BIOMAT project, funded by the European Commission in the Horizon 2020 framework (Grant Agreement nr.) with the aim of establishing an Open Innovation Test Bed (BIOMAT-TB) with a Single-Entry Point (SEP) . The aim of this project is to accelerate a sustainable European bioeconomy through the development of nanomaterial-based and advanced polyurethane foams (PUR Foams) for various companies (building, construction, automotive, furniture, textiles).

Project ID:953270; Call ID: H2020-EU.2.1.3. – INDUSTRIAL LEADERSHIP – Leadership in enabling and industrial technologies – Advanced materials;   H2020-EU.2.1.2. – INDUSTRIAL LEADERSHIP – Leadership in enabling and industrial technologies – Nanotechnologies

Project coordinator: Dr. Mariana Ornelas (CENTI)

Dissemination Manager: Dr. Pnina Dan (OSM-DAN LTD).

Partner UNIMIB – POLARIS Prof. Paride Mantecca is leader of WP7 – Recycling technologies, nanosafety and regulatory issues with specific focus on Nanosafety and toxicology (Task 7.2).

Further information can be found at the link.

New Article published!

sara.marchetti1@unimib.it News and Events, Publications , ,
New Article published!

What is the connection between pollution and COVID19?

The POLARIS “Health and Environmental Sustainability” Research Centre has demonstrated how air pollution can play a crucial role in the transmission of the SARS-CoV-2 virus and the resulting severity of the COVID-19 disease. The study, recently published in the journal Environment International, paves the way for a greater understanding of how atmospheric particulate matter can influence and facilitate the possibility of contracting respiratory diseases transmitted by viruses or bacteria and provides fundamental information to understand how the population responds to the same threat depending on the quality of the environment in which it lives.

To find out more, read the interview with our researchers, edited by the press office of the University of Milan-Bicocca.

Further information on Environment International:

Marchetti S, Gualtieri M, Pozzer A, Lelieveld J, Saliu F, Hansell AL, Colombo A, Mantecca P. On fine particulate matter and COVID-19 spread and severity: An in vitro toxicological plausible mechanism.

 

Research

sara.marchetti1@unimib.it Research

The Interdepartmental Research Centre called “Environmental Health and Sustainability – POLARIS” aims to increase and integrate the state of knowledge in the following macro-areas of research.

AIR QUALITY AND HEALTH

Monitoring of air quality in indoor and outdoor environments and study of the impact on human and environmental health, with focus on the presence of air contaminants and the spread of pathogens.

Recent Projects:

To find out more, visit the dedicated page

INNOVATIVE, SAFE AND SUSTAINABLE TECHNOLOGIES

Support for the development of safe, sustainable and innovative (nano)technologies, with assessment of their safety during the entire life cycle (circularity). Study of emerging contaminants, their impact on health and risk prevention and mitigation strategies.

Recent Projects:

To find out more, visit the dedicated page

ENVIRONMENTAL ECONOMICS AND SOCIOLOGY

Evaluation of the environmental, economic and social impacts of products and processes; development of environmental policies with a view to sustainability and circularity.

Recent Projects:

To find out more, visit the dedicated page

Scientific Publications 2022

sara.marchetti1@unimib.it Publications, Research
  • Bengalli B, Zerboni A, Bonfanti P, Saibene M, Mehn D, Cella C, Ponti J, La Spina R, Mantecca P. Characterization of microparticles derived from waste plastics and their bio-interaction with human lung A549 cells. J Appl Toxicol. 2022 Dec;42(12):2030-2044. doi: 10.1002/jat.4372. Epub 2022 Aug 30. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jat.4372
  • Bonfanti P, Colombo A, Saibene M, Motta G, Saliu F, Catelani T, Mehn D, La Spina R, Ponti J, Cella C, Floris P, Mantecca P. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development. Ecotoxicol Environ Saf. 2021 Dec 1;225:112775. doi: 10.1016/j.ecoenv.2021.112775. Epub 2021 Sep 15. https://www.sciencedirect.com/science/article/pii/S0147651321008873
  • Bragato C, Mostoni S, D’Abramo C, Gualtieri M, Pomilla FR, Scotti R, Mantecca P. On the In Vitro and In Vivo Hazard Assessment of a Novel Nanomaterial to Reduce the Use of Zinc Oxide in the Rubber Vulcanization Process. Toxics. 2022; 10(12):781. https://doi.org/10.3390/toxics10120781
  • Ferrero L, Scibetta L, Markuszewski P, Mazurkiewicz M, Drozdowska V, Makuch P, Jutrzenka-Trzebiatowska P, Zaleska-Medynska A, Andò S, Saliu F, Nilsson E. D, Bolzacchini E. Airborne and marine microplastics from an oceanographic survey at the Baltic Sea: An emerging role of air-sea interaction? Sci Total Environ. 2022 Jun 10;824:153709. doi: 10.1016/j.scitotenv.2022.153709. Epub 2022 Feb 9. https://pubmed.ncbi.nlm.nih.gov/35150686/
  • Ivanova A, Ivanova K, Fiandra L, Mantecca P, Catelani T, Natan M, Banin E, Jacobi G, Tzanov T. Antibacterial, Antibiofilm, and Antiviral Farnesol-Containing Nanoparticles Prevent Staphylococcus aureus from Drug Resistance Development. Int J Mol Sci. 2022 Jul 7;23(14):7527. doi: 10.3390/ijms23147527. https://www.mdpi.com/1422-0067/23/14/7527
  • Massimino L, Bulbarelli A, Corsetto P. A, Milani C, Botto L, Farina F, Lamparelli L. A, Lonati E, Ungaro F, Maddipati K. R, Palestini P, Rizzo A. M. LSEA Evaluation of Lipid Mediators of Inflammation in Lung and Cortex of Mice Exposed to Diesel Air Pollution. Biomedicines. 2022 Mar 19;10(3):712. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945792/
  • Perucca, M.; Capuano, L.; Magatti, G.; Rosa, F.; Mantecca, P. Environmental Performance of Road Asphalts Modified with End-of-Life Hard Plastics and Graphene: Strategies for Improving Sustainability. Processes 2022, 10, 2151. https://doi.org/10.3390/pr10102151
  • Traina G, Bolzacchini E, Bonini M, Contini D, Mantecca P, Caimmi S. M. E, Licari A. Role of air pollutants mediated oxidative stress in respiratory diseases. Pediatr Allergy Immunol. 2022 Jan;33 Suppl 27(Suppl 27):38-40. https://pubmed.ncbi.nlm.nih.gov/35080317/
  • Zerboni A, Rossi T, Bengalli R, Catelani T, Rizzi C, Priola M, Casadei S, Mantecca P. Diesel exhaust particulate emissions and in vitro toxicity from Euro 3 and Euro 6 vehicles. Environ Pollut. 2022 Mar 15;297:118767. https://www.sciencedirect.com/science/article/pii/S0269749121023496?via%3Dihub

Scientific Publications 2021

sara.marchetti1@unimib.it Publications, Research, Scientific Publications Archive
  • Bengalli R, Fiandra L, Vineis C, Sanchez-Ramirez DO, Azoia NG, Varesano A, Mantecca P. Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles. Nanomaterials (Basel).2021 Aug 3;11(8):1991. https://doi.org/10.3390/nano11081991
  • Bengalli R, Colantuoni A, Perelshtein I, Gedanken A, Collini M, Mantecca P, Fiandra L. In vitro skin toxicity of CuO and ZnO nanoparticles: Application in the safety assessment of antimicrobial coated textiles. 2021 Jan;21:100282. doi: 10.1016/j.impact.2020.100282. Epub 2020 Dec 7. https://doi.org/10.1016/j.impact.2020.100282
  • Bertero A, Colombo G, Cortinovis C, Bassi V, Moschini E, Bellitto N, Perego MC, Albonico M, Astori E, Dalle-Donne I, Gedanken A, Perelshtein I, Mantecca P, Caloni F. In vitro copper oxide nanoparticle toxicity on intestinal barrier. J Appl Toxicol. 2021 Feb;41(2):291-302. https://doi.org/10.1002/jat.4047
  • Bonfanti P, Colombo A, Saibene M, Motta G, Saliu F, Catelani T, Mehn D, La Spina R, Ponti J, Cella C, Floris P, Mantecca P. Microplastics from miscellaneous plastic wastes: Physico-chemical characterization and impact on fish and amphibian development. Ecotoxicol Environ Saf. 2021 Dec 1;225:112775. https://doi.org/10.1016/j.ecoenv.2021.112775
  • Botto L, Bulbarelli A, Lonati E, Cazzaniga E, Tassotti M, Mena P, Del Rio D, Palestini P. Study of the Antioxidant Effects of Coffee Phenolic Metabolites on C6 Glioma Cells Exposed to Diesel Exhaust Particles. Antioxidants (Basel). 2021 Jul 23;10(8):1169. https://doi.org/10.3390/antiox10081169
  • Deokar AR, Perelshtein I, Saibene M, Perkas N, Mantecca P, Nitzan Y, Gedanken A. Antibacterial and In Vivo Studies of a Green, One-Pot Preparation of Copper/Zinc Oxide Nanoparticle-Coated Bandages. Membranes (Basel). 2021 Jun 22;11(7):462. https://doi.org/10.3390/membranes11070462
  • Floris P, Garbujo S, Rolla G, Giustra M, Salvioni L, Catelani T, Colombo M, Mantecca P, Fiandra L. The Role of Polymeric Coatings for a Safe-by-Design Development of Biomedical Gold Nanoparticles Assessed in Zebrafish Embryo. Nanomaterials (Basel). 2021 Apr 14;11(4):1004. https://doi.org/10.3390/nano11041004
  • Furxhi I, Bengalli R, Motta G, Mantecca P, Kose O, Carriere M, Haq EU, O’Mahony C, Blosi M, Gardini D, Costa A. Data-Driven Quantitative Intrinsic Hazard Criteria for Nanoproduct Development in a Safe-by-Design Paradigm: A Case Study of Silver Nanoforms. ACS Appl Nano Mater. 2023 Feb 16;6(5):3948-3962. doi: 10.1021/acsanm.3c00173. eCollection 2023 Mar 10. https:// org/10.1021/acsanm.3c00173
  • Kose O, Béal D, Motellier S, Pelissier N, Collin-Faure V, Blosi M, Bengalli R, Costa A, Furxhi I, Mantecca P, Carriere M. Physicochemical Transformations of Silver Nanoparticles in the Oro-Gastrointestinal Tract Mildly Affect Their Toxicity to Intestinal Cells In Vitro: An AOP-Oriented Testing Approach. Toxics. 2023 Feb 21;11(3):199. https://doi.org/10.3390/toxics11030199
  • Marchetti S., Mollerup S., Gutzkow K. B., Rizzi C., Skuland T., Refsnes M., Colombo A., Øvrevik J, Mantecca P., Holme J. A. “Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells” Toxicol in Vitro 2021 May 5;105190. https://doi.org/10.1016/j.tiv.2021.105190
  • Marchetti S., Bengalli R., Floris P., Colombo A., Mantecca P. “Combustion-derived particles from biomass sources differently promote epithelial to mesenchymal transition on A549 cells” Arch Toxicol. 2021, Jan 22. https://doi.org/10.1007/s00204-021-02983-8
  • Pacitto A, Stabile L, Morawska L, Nyarku M, Torkmahalleh MA, Akhmetvaliyeva Z, Andrade A, Dominski FH, Mantecca P, Shetaya WH, Mazaheri M, Jayaratne R, Marchetti S, Hassan SK, El-Mekawy A, Mohamed EF, Canale L, Frattolillo A, Buonanno G.Daily submicron particle doses received by populations living in different low- and middle-income countries. Environ Pollut. 2021 Jan 15;269:116229.https://doi.org/10.1016/j.envpol.2020.116229
  • Zerboni A, Bengalli R, Fiandra L, Catelani T, Mantecca P. Cellular Mechanisms Involved in the Combined Toxic Effects of Diesel Exhaust and Metal Oxide Nanoparticles. Nanomaterials (Basel). 2021, May 29;11(6):1437.https://doi.org/10.3390/nano11061437

Scientific Publications 2020

sara.marchetti1@unimib.it Publications, Research, Scientific Publications Archive
  • Bonfanti P, Colombo A, Saibene M, Fiandra L, Armenia I, Gamberoni F, Gornati R, Bernardini G, Mantecca P. Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles. Nanotoxicology. 2020 Mar;14(2):196-213. https://doi.org/10.1080/17435390.2019.1685695
  • Borgese M, Rossi F, Bonfanti P, Colombo A, Mantecca P, Valdatta L, Bernardini G, Gornati R. Recovery ability of human adipose stem cells exposed to cobalt nanoparticles: outcome of dissolution. Nanomedicine (Lond). 2020 Feb;15(5):453-465. https://doi.org/10.2217/nnm-2019-0195
  • Comunian S, Dongo D, Milani C, Palestini P. Air Pollution and Covid-19: The Role of Particulate Matter in the Spread and Increase of Covid-19’s Morbidity and Mortality. Int J Environ Res Public Health. 2020 Jun 22;17(12):4487. https://doi.org/10.3390/ijerph17124487
  • Longhin EM, Mantecca P, Gualtieri M.Fifteen Years of Airborne Particulates in Vitro Toxicology in Milano: Lessons and Perspectives Learned. Int J Mol Sci. 2020 Apr 3;21(7):2489. https://doi.org/10.3390/ijms21072489
  • Milani C, Farina F, Botto L, Massimino L, Lonati E, Donzelli E, Ballarini E, Crippa L, Marmiroli P, Bulbarelli A, Palestini P. Systemic Exposure to Air Pollution Induces Oxidative Stress and Inflammation in Mouse Brain, Contributing to Neurodegeneration Onset. Int J Mol Sci. 2020 May 24;21(10):3699. https://doi.org/10.3390/ijms21103699
  • Traina G, Barbalace A, Betti F, Bolzacchini E, Bonini M, Contini D, Felice G, Foti T, Mantecca P. What impact of air pollution in pediatric respiratory allergic diseases. Pediatr Allergy Immunol. 2020 Nov;31 Suppl 26:26-28. https://doi.org/10.1111/pai.13362